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【Detail】

Application of PVP-I in healthcare

Application of PVP in sterilization and disinfectants is the most successful example. PVP excellent unique complexation of small molecule ability with I resulting in complexes of Povidone - Iodine, which has been recorded into the United States Pharmacopoeia, British Pharmacopoeia, Japan Pharmacopoeia, China Pharmacopoeia, Martin Pharmacopoeia, approved in the medical and health and the human body directly with sanitizer. Chinese Pharmacopoeia records povidone - iodine suppositories, solution, ointment form. Povidone - iodine is now internationally recognized as effective, broad-spectrum, non-toxic fungicide, which has strong bactericidal power and extremely broad spectrum of sterilization.

Mechanism of Action: PVP is a hydrophilic polymer without antibacterial effect, however, due to its affinity to the cell membrane function, directly leads iodine to the bacterial cell surface, which means a lot to improve the activity of iodine. Iodine attack target is that the bacterial cytoplasmic membrane and cytoplasm immediately kills the bacteria in a few seconds. When mercapto compounds, peptide, protein, lipid and cytosine molecules necessary for life after contact with PVP-I, they are oxidation of iodine or iodine to loss of activity in order to have long time bactericidal effect. PVP-I has killing effect on bacteria, fungi, viruses and protozoa, common bacteria for in vitro experiments on the clinical, almost kill bacterias. In vitro experiment of common bacteria in clinical, almost no bacteria can't be killed.

Antimicrobial spectrum: Povidone - iodine against many gram - positive and - negative bacteria, spore, fungi, escherichia coli, dysentery bacillus, terads, bacillus subtilis, proteus, pseudomonas aeruginosa, neisseria gonorrhoeae, Aeromonas malt false single bacteria, citrobacter, diphtheroid bacillus , Wrapping bacili,  Bacillus anthracoides, candida albicans, flagellates and chlamydia.

Usage: mainly used in gynecological inflammation, tinea sore skin inflammation, oral inflammation, mouth ulcers and burns, scalds, all kinds of trauma, surgery, injections in skin disinfection and sterilization for medical devices, and so on.

Using density and methods: povidone - iodine solution diluted, according to the disinfection objects, correspondingly density can be made. See the attachment of its density and disinfection methods: quote from Clinical Handbook of National Essential Medicines List:

Application of PVP-I in food and food hygiene

PVP-I with excellent sterilization capability and its physiological compatibility, showing the human body without irritation and allergic reactions, also has a wide range of uses in food preservation and disinfection of restaurants. In some ways it shows unique advantages, such as 0.1% PVP-I solution sprayed the refrigerator once a week, can guarantee the long-term without peculiar smell in the fridge. Density and method of PVP-I used in food and Food Hygiene industry are shown in the table below:

Application of PVP-I in aquaculture is developed in recent years, and is further expanding the scope of use. With the further development of the aquaculture industry in China, as breeding disinfectant PVP-I has broad prospects. PVP-I as broad-spectrum disinfectant, has different levels of kill for the majority of bacteria, fungi and viruses and treats fish, shellfish, shrimp, crab disease of prevention and treatment. There have been noticeable effects on disinfection and treatment of diseases in livestock and poultry breeding. Density and methods of PVP-I used in the aquaculture industry shown in the table below ( with a density of 1% povidone - iodine solution )